Generic Chloromycetin

Chloromycetin (Chloramphenicol 250 mg)
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Manufacturer: Abbott Laboratories
Chloromycetin, also known as Chloramphenicol, is a widely used antibiotic that belongs to a class of drugs known as bacteriostatic agents which inhibit bacterial growth by inhibiting protein synthesis.

Chloromycetin is prescribed primarily for serious infections caused by various bacteria, including respiratory tract infections, meningitis, and typhoid fever. This antibiotic is particularly effective against Gram-negative and some Gram-positive bacteria such as Haemophilus influenzae, Escherichia coli, Salmonella typhi, and Streptococcus pneumoniae.

One of the unique features of Chloromycetin is its ability to penetrate various bodily tissues effectively, including the brain, making it highly effective in treating central nervous system infections. This property allows it to combat rare and severe infections, such as meningitis caused by multidrug-resistant bacteria.

The mechanism of action of Chloromycetin involves binding to the 50S subunit of the bacterial ribosome, thereby inhibiting the enzymatic activity responsible for protein synthesis. This disruption prevents the bacteria from producing essential proteins necessary for their survival and growth, eventually leading to their destruction.

Chloromycetin is available in various formulations, including oral capsules, eye drops, and intravenous injections. The appropriate form and dosage depend on the type and severity of the infection, as well as the patient's age and overall health condition. It is crucial to strictly follow the prescribed dosage and complete the full course of treatment, even if symptoms improve, to prevent the development of drug-resistant bacteria.

While Chloromycetin is generally considered safe and well-tolerated, it can cause certain side effects. The most common side effects include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. In rare cases, it may lead to more serious adverse reactions, including aplastic anemia, a potentially life-threatening condition characterized by bone marrow suppression.

Due to the risk of serious side effects, Chloramphenicol is reserved for the treatment of severe infections when other antibiotics have failed or are contraindicated. It is not recommended for use in pregnant women, individuals with a history of bone marrow depression, or those with a known hypersensitivity to the drug.

Chloromycetin (Chloramphenicol) is a potent antibiotic with a broad spectrum of activity against bacteria. Its unique ability to penetrate various tissues, including the brain, makes it a crucial drug in the treatment of severe infections, especially those caused by multidrug-resistant bacteria. However, caution must be exercised due to the potential for serious side effects. It should only be used under the supervision and guidance of a healthcare professional, strictly following the prescribed dosage and duration of treatment.

Technical Information

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Chloromycetin: Paraxin (Abbott Laboratories)

Imprints: Chloromycetin (chloramphenicol) P-D 379

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