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Manufacturer: Martin & Harris, Ranbaxy
Furadantin, also known as Nitrofurantoin, is a potent antibiotic drug that is primarily used to treat urinary tract infections (UTIs) caused by bacteria. This medication belongs to the class of drugs known as nitrofuran antibiotics. Nitrofurantoin works by inhibiting the production of certain proteins that are essential for the growth and survival of bacteria, thereby stopping their growth and killing them.

One of the key benefits of Furadantin is its excellent efficacy against a wide range of bacteria commonly involved in UTIs, including Escherichia coli, Enterococcus, Staphylococcus, and Klebsiella species. It is particularly effective against these gram-negative bacteria that often cause uncomplicated lower urinary tract infections. Furthermore, Furadantin displays favorable activity against strains of bacteria that are resistant to other commonly used antibiotics, making it a valuable option in the management of complicated and recurrent UTIs.

This medication is available in both oral suspension and capsule forms, providing flexibility in administration depending on patient preference and clinical situation. The suspension form is especially beneficial for pediatric patients who may have difficulty swallowing capsules. It is generally recommended to take Furadantin with food or milk to help improve absorption and decrease the likelihood of gastrointestinal side effects.

Furadantin is known for its excellent tissue penetration, with high concentrations achieved in the urine, which is crucial in effectively treating UTIs. The drug is rapidly excreted by the kidneys, resulting in high urinary concentrations that exceed the minimum inhibitory concentration (MIC) required to eradicate the bacteria causing the infection.

In addition to its effectiveness, Furadantin is favored for its safety profile. It is well-tolerated with minimal side effects, which commonly include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. These adverse effects are generally mild and transient. Rarely, serious side effects like pulmonary toxicity, hepatotoxicity, and peripheral neuropathy have been reported, but they are extremely infrequent.

It is important to note that Furadantin should not be used in individuals with an allergy or hypersensitivity to nitrofurantoin. Furthermore, it is essential to complete the full course of treatment as prescribed, even if symptoms improve, to fully eradicate the infection and prevent recurrence.

As with any medication, Furadantin may interact with other drugs, so it is important to inform the healthcare provider of all medications being taken to avoid potential drug interactions or reduced efficacy. It is also important to inform the healthcare provider if any pre-existing medical conditions, such as kidney or liver disease, are present.

Furadantin (Nitrofurantoin) is an effective and well-tolerated antibiotic used primarily for the treatment of UTIs. Its exceptional spectrum of activity, favorable pharmacokinetic properties, and low incidence of side effects make it an ideal choice for managing both uncomplicated and complicated urinary tract infections. However, as with any medication, it should be used judiciously, taking into consideration individual patient factors and antimicrobial stewardship principles.

Technical Information

Brand names: Alfuran, Benkfuran, Berkfurin, Ceduran, Chemiofuran, Cistofuran, Cyantin, Cystit, Dantafur, Fuamed, Fur-Ren, Furabid, Furachel, Furadantin, Furadantine, Furadantoin, Furadoin, Furadoine, Furadonin, Furadonine, Furadontin, Furalan, Furaloid, Furan, Furanite, Furantoin, Furantoina, Furatoin, Furedan, Furina, Furobactina, Furophen T, Gerofuran, Ituran, Ivadantin, Macpac, Macrobid, Macrodantin, Macrodantina, Macrofuran, Macrofurin, Nierofu, Nifurantin, Nitoin, Nitrex, Nitrofan, Nitrofur-C, Nitrofuradantin, Novofuran, Orafuran, Parfuran, Phenurin, Ro-Antoin, Siraliden, Trantoin, Uerineks, Upiol, Urantoin, Urizept, Uro-Selz, Uro-Tablinen, Urodin, Urofuran, Urofurin, Urolisa, Urolong, Uvaleral, Welfurin, Zoofurin

Furadantin: Martifur (Martin & Harris), Niftran (Ranbaxy)

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