Generic Monurol

A broad-spectrum antibiotic, a derivative of phosphonic acid, has a bactericidal effect, the mechanism of which is associated with the suppression of the first stage of the synthesis of the bacterial cell wall. It is a structural analog of phosphoenol pyruvate, enters into a competitive interaction with the enzyme N-acetyl-glucosamine-3-o-enolpyruvyl transferase. As a result, a specific, selective and irreversible inhibition of this enzyme occurs, which ensures the absence of cross-resistance with other classes of antibiotics and the possibility of synergy with other antibiotics (in vitro, synergism with amoxicillin, cephalexin, pipemidic acid is noted).

It is active in vitro against most Gram-positive microorganisms: Enterococcus spp., Enterococcus faecalis, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus spp.; Gram-negative microorganisms: Esherichia coli, Citrobacter spp., Enterobacter spp., Klebsiella spp., Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Pseudomonas spp., Serratia spp. In vitro, fosfomycin reduces the adhesion of a number of bacteria on the epithelium of the urinary tract.